Changes in Forced Expiratory Volume in 1 Second over Time in COPD

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Changes in forced expiratory volume in 1 second over time in COPD.

BACKGROUND A key feature of chronic obstructive pulmonary disease (COPD) is an accelerated rate of decline in forced expiratory volume in 1 second (FEV(1)), but data on the variability and determinants of this change in patients who have established disease are scarce. METHODS We analyzed the changes in FEV(1) after administration of a bronchodilator over a 3-year period in 2163 patients. A r...

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BACKGROUND There are limited studies directly comparing correlation and agreement between peak expiratory flow rate (PEFR) and forced expiratory volume in 1 second (FEV1) for severity classification of COPD. However, clarifying the role of PEFR as a surrogate of COPD severity classification instead of FEV1 is essential in situations and areas where spirometry is not routinely available. PURPO...

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Effort and the forced expiratory volume in one second (FEV).

1. The relationship between volumes expired and the maximum intrathoracic pressures developed within the first second of expiration was examined in a group of healthy subjects and patients with airways obstruction who exhaled with varying degrees of effort. 2. The body plethysmographic method was used to ensure that expirations started from total lung capacity. 3. Three different types of volum...

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Numerous epidemiological surveys have tried to evaluate the effects of exposures relevant to pulmonary disease.' A number of studies have analysed forced expiratory volume in one second (FEVI) using linear regression analysis, thus enabling adjustment for age, height, and sex as well as potential confounding variables. Within the last few years, studies analysing dichotomous FEV, variables with...

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ژورنال

عنوان ژورنال: New England Journal of Medicine

سال: 2011

ISSN: 0028-4793,1533-4406

DOI: 10.1056/nejmoa1105482